Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects
Nano Letters2006Vol. 6(4), pp. 669–676
Citations Over TimeTop 1% of 2006 papers
Weibo Cai, Dongwoon Shin, Kai Chen, Olivier Gheysens, Qizhen Cao, Shan X. Wang, Sanjiv S. Gambhir, Xiaohong Chen
Abstract
We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
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