Quantum Dots for Human Mesenchymal Stem Cells Labeling. A Size-Dependent Autophagy Activation
Nano Letters2006Vol. 6(12), pp. 2826–2832
Citations Over TimeTop 10% of 2006 papers
Oleksandr Seleverstov, Olga Zabirnyk, Matthias Zscharnack, Larysa Bulavina, Marcin Nowicki, Jan‐Michael Heinrich, Maksym Yezhelyev, Frank Emmrich, Ruth O’Regan, Augustinus Bader
Abstract
Lately certain cytotoxicity of quantum dots (QDs) and some deleterious effects of labeling procedure on stem cells differentiation abilities were shown. In the present study we compared cytotoxicity and intracellular processing of two different-sized protein-conjugated QDs after labeling of the human mesenchymal stem cells (hMSC). An asymmetrical intracellular uptake of red (605 nm) and green (525 nm) quantum dots was observed. We describe for the first time a size-dependent activation of autophagy, caused by nanoparticles.
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