Immuno Gold Nanocages with Tailored Optical Properties for Targeted Photothermal Destruction of Cancer Cells
Citations Over TimeTop 1% of 2007 papers
Abstract
Gold nanocages with a relatively small size (e.g., approximately 45 nm in edge length) have been developed, and the structure of these nanocages was tailored to achieve strong absorption in the near-infrared (NIR) region for photothermal cancer treatment. Numerical calculations show that the nanocage has a large absorption cross section of 3.48 x 10(-14) m(2), facilitating conversion of NIR irradiation into heat. The gold nanocages were conjugated with monoclonal antibodies (anti-HER2) to target epidermal growth factor receptors (EGFR) that are overexpressed on the surface of breast cancer cells (SK-BR-3). Our preliminary photothermal results show that the nanocages strongly absorb light in the NIR region with an intensity threshold of 1.5 W/cm(2) to induce thermal destruction to the cancer cells. In the intensity range of 1.5-4.7 W/cm(2), the circular area of damaged cells increased linearly with the irradiation power density. These results suggest that this new class of bioconjugated gold nanostructures, immuno gold nanocages, can potentially serve as an effective photothermal therapeutic agent for cancer treatment.
Related Papers
- → Photothermal Efficiencies of Nanoshells and Nanorods for Clinical Therapeutic Applications(2009)374 cited
- → Differential photothermal and photodynamic performance behaviors of gold nanorods, nanoshells and nanocages under identical energy conditions(2019)38 cited
- → Shape Matters: Gold Nanoparticle Shape Impacts the Biological Activity of siRNA Delivery(2019)50 cited
- → Gold Nanocages as Effective Photothermal Transducers in Killing Highly Tumorigenic Cancer Cells(2013)36 cited
- Using gold nanorods and nanoshells in photothermal cancer therapy(2014)