Bioactive Nanofibers: Synergistic Effects of Nanotopography and Chemical Signaling on Cell Guidance
Citations Over TimeTop 1% of 2007 papers
Abstract
Biodegradable nanofibers have tremendous potential for tissue repair. However, the combined effects of nanofiber organization and immobilized bioactive factors on cell guidance are not well understood. In this study, we developed aligned and bioactive nanofibrous scaffolds by immobilizing extracellular matrix protein and growth factor onto nanofibers, which simulated the physical and biochemical properties of native matrix fibrils. The aligned nanofibers significantly induced neurite outgrowth and enhanced skin cell migration during wound healing compared to randomly oriented nanofibers. Furthermore, the immobilized biochemical factors (as efficient as soluble factors) synergized with aligned nanofibers to promote highly efficient neurite outgrowth but had less effect on skin cell migration. This study shed light on the relative importance of nanotopography and chemical signaling in the guidance of different cell behavior.
Related Papers
- → Tuning Chemistry and Topography of Nanoengineered Surfaces to Manipulate Immune Response for Bone Regeneration Applications(2017)292 cited
- → Small surface nanotopography encourages fibroblast and osteoblast cell adhesion(2013)70 cited
- → Nanotopography Drives Stem Cell Fate Toward Osteoblast Differentiation Through α1β1 Integrin Signaling Pathway(2013)79 cited
- → Stem cell responses to nanotopography(2014)46 cited
- → A Systematic Study of Cell Mechanics and Function Modulated by Nanotopography(2019)