A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response
Nano Letters2008Vol. 8(3), pp. 859–865
Citations Over TimeTop 10% of 2008 papers
Hongyu Zhou, Qingxin Mu, Ningning Gao, Aifeng Liu, Yuehan Xing, Sulian Gao, Qiu Zhang, Guangbo Qu, Yuyan Chen, Gang Liu, Bin Zhang, Bing Yan
Abstract
We have discovered functionalized multiwalled carbon nanotubes with reduced protein-binding, cytotoxicity, and immune response and the associated structure-activity relationships using in silico surface molecular diversity design, combinatorial library synthesis, and multiple biological screenings. Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research.
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