Modulation of in Vivo Tumor Radiation Response via Gold Nanoshell-Mediated Vascular-Focused Hyperthermia: Characterizing an Integrated Antihypoxic and Localized Vascular Disrupting Targeting Strategy
Nano Letters2008Vol. 8(5), pp. 1492–1500
Citations Over TimeTop 1% of 2008 papers
Parmeswaran Diagaradjane, Anil Shetty, James C. Wang, Andrew M. Elliott, Jon A. Schwartz, Shujun Shentu, Hee C. Park, Amit Deorukhkar, R. Jason Stafford, Sang Hyun Cho, James W. Tunnell, John D. Hazle, Sunil Krishnan
Abstract
We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.
Related Papers
- → Controlling the Topography and Surface Plasmon Resonance of Gold Nanoshells by a Templated Surfactant-Assisted Seed Growth Method(2013)54 cited
- → Evaluation of theranostic perspective of gold-silica nanoshell for cancer nano-medicine: a numerical parametric study(2018)6 cited
- → Theoretical Study on the Local Electric Field Factor and Sensitivity of Bimetallic Three-Layered Nanoshell Using Quasi-Approximation(2021)4 cited
- → Energy Absorption in Gold Nanoshells(2013)4 cited
- → Nanoshells for Drug Delivery(2003)8 cited