Nanofluidic Biosensing for β-Amyloid Detection Using Surface Enhanced Raman Spectroscopy
Nano Letters2008Vol. 8(6), pp. 1729–1735
Citations Over TimeTop 10% of 2008 papers
I-Hsien Chou, Melodie Benford, Hope T. Beier, Gerard L. Coté, Miao Wang, Nan Jing, Jun Kameoka, Theresa A. Good
Abstract
Trace detection of the conformational transition of beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe Abeta in different conformational states during the Abeta self-assembly process as well as to distinguish Abeta from confounder proteins commonly found in cerebral spinal fluid.
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