Protein−Nanoparticle Interaction: Identification of the Ubiquitin−Gold Nanoparticle Interaction Site
Nano Letters2010Vol. 10(8), pp. 3101–3105
Citations Over TimeTop 10% of 2010 papers
Abstract
We demonstrate that it is possible to identify the protein--nanoparticle interaction site at amino acid scale in solution. Using NMR, chemical shift perturbation analysis, and dynamic light scattering we have identified a specific domain of human ubiquitin that interacts with gold nanoparticles. This method allows a detailed structural analysis of proteins absorbed onto surfaces of nanoparticles in physiological conditions and it will provide much needed experimental data for better modeling and prediction of protein--nanoparticle interactions.
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