Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings
Nano Letters2011Vol. 11(2), pp. 808–813
Citations Over TimeTop 10% of 2011 papers
Abstract
Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.
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