Cancer-Targeted Optical Imaging with Fluorescent Zinc Oxide Nanowires
Nano Letters2011Vol. 11(9), pp. 3744–3750
Citations Over TimeTop 10% of 2011 papers
Hao Hong, Jian Shi, Yunan Yang, Yin Zhang, Jonathan W. Engle, Robert J. Nickles, Xudong Wang, Weibo Cai
Abstract
Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to render water solubility, biocompatibility, and low cellular toxicity. Optical imaging of integrin α(v)β(3) on U87MG human glioblastoma cells was achieved with RGD peptide-conjugated green fluorescent ZnO NWs, which opened up new avenues of research for investigating ZnO NW-based agents in tumor vasculature-targeted molecular imaging and drug delivery.
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