Full Surface Embedding of Gold Clusters on Silicon Nanowires for Efficient Capture and Photothermal Therapy of Circulating Tumor Cells
Nano Letters2012Vol. 12(3), pp. 1638–1642
Citations Over TimeTop 10% of 2012 papers
Gyeong‐Su Park, HyukSang Kwon, Dong Wook Kwak, Sung Yong Park, Minseok Kim, Jun-Ho Lee, Hyouksoo Han, Sung Heo, Xiang Shu Li, Jae‐Hak Lee, Young Hwan Kim, Jeong‐Gun Lee, Woochul Yang, Hoon Young Cho, Seong Keun Kim, Kinam Kim
Abstract
We report on rapid thermal chemical vapor deposition growth of silicon nanowires (Si NWs) that contain a high density of gold nanoclusters (Au NCs) with a uniform coverage over the entire length of the nanowire sidewalls. The Au NC-coated Si NWs with an antibody-coated surface obtain the unique capability to capture breast cancer cells at twice the highest efficiency currently achievable (~88% at 40 min cell incubation time) from a nanostructured substrate. We also found that irradiation of breast cancer cells captured on Au NC-coated Si NWs with a near-infrared light resulted in a high mortality rate of these cancer cells, raising a fine prospect for simultaneous capture and plasmonic photothermal therapy for circulating tumor cells.
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