Gold Nanoparticle-Induced Formation of Artificial Protein Capsids
Nano Letters2012Vol. 12(4), pp. 2056–2059
Citations Over TimeTop 21% of 2012 papers
Ali D. Malay, Jonathan G. Heddle, Satoshi Tomita, Kenji Iwasaki, Naoyuki Miyazaki, Koji Sumitomo, Hisao Yanagi, Ichiro Yamashita, Yukiharu Uraoka
Abstract
Gold nanoparticles are generally considered to be biologically inactive. However, in this study we show that the addition of 1.4 nm diameter gold nanoparticle induces the remodeling of the ring-shaped protein TRAP into a hollow, capsid-like configuration. This structural remodeling is dependent upon the presence of cysteine residues on the TRAP surface as well as the specific type of gold nanoparticle. The results reveal an apparent novel catalytic role of gold nanoparticles.
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