Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo
Nano Letters2013Vol. 13(6), pp. 2528–2534
Citations Over TimeTop 10% of 2013 papers
Tuo Wei, Juan Liu, Huili Ma, Qiang Cheng, Yuanyu Huang, Jing Zhao, Shuaidong Huo, Xiangdong Xue, Zicai Liang, Xing‐Jie Liang
Abstract
Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.
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