Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment
Nano Letters2015Vol. 15(4), pp. 2249–2256
Citations Over TimeTop 1% of 2015 papers
Hongmin Chen, Geoffrey D. Wang, Yen-Jun Chuang, Zipeng Zhen, Xiaohong Chen, Paul W. Biddinger, Zhonglin Hao, Feng Liu, Baozhong Shen, Zhengwei Pan, Jin Xie
Abstract
Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.
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