Noninvasive Raman Spectroscopy in Living Mice for Evaluation of Tumor Targeting with Carbon Nanotubes
Nano Letters2008Vol. 8(9), pp. 2800–2805
Citations Over TimeTop 1% of 2008 papers
Cristina Zavaleta, Adam de la Zerda, Zhuang Liu, Shay Keren, Zhen Cheng, Meike L. Schipper, Xinyue Chen, Hongjie Dai, Sanjiv S. Gambhir
Abstract
An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
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