Role of Polyethylene Glycol Integrity in Specific Receptor Targeting of Carbon Nanotubes to Cancer Cells
Nano Letters2009Vol. 9(2), pp. 751–757
Citations Over TimeTop 10% of 2009 papers
Abstract
We demonstrate that dispersion of single walled carbon nanotubes (SWNTs) by ultrasonication with phospholipid-polyethylene glycol (PL-PEG) fragments it, thus interfering with its ability to block nonspecific uptake by cells. However, unfragmented PL-PEG promoted specific cellular uptake of targeted SWNTs to two distinct classes of receptors expressed by cancer cells. Since fragmentation is a likely consequence of ultrasonication, a technique commonly used to disperse SWNTs, this maybe a concern for certain applications such as drug delivery.
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