Long-Term Small Molecule and Protein Elution from TiO2 Nanotubes
Nano Letters2009Vol. 9(5), pp. 1932–1936
Citations Over TimeTop 10% of 2009 papers
Abstract
In this study, TiO(2) nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO(2) nanotubes may be a promising candidate for a drug-eluting implant coating.
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