Polymeric Nanoparticle-Based Activatable Near-Infrared Nanosensor for Protease Determination In Vivo
Nano Letters2009Vol. 9(12), pp. 4412–4416
Citations Over TimeTop 10% of 2009 papers
Seulki Lee, Ju Hee Ryu, Kyeongsoon Park, Aeju Lee, Seung Young Lee, In-Chan Youn, Cheol-Hee Ahn, Soon Man Yoon, Seung‐Jae Myung, Dae Hyuk Moon, Xiaohong Chen, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim
Abstract
We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.
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