Large Area Protein Patterning Reveals Nanoscale Control of Focal Adhesion Development
Nano Letters2010Vol. 10(2), pp. 686–694
Citations Over TimeTop 10% of 2010 papers
Jenny Malmström, Brian Christensen, Hans Plesner Jakobsen, Jette Lovmand, Rasmus Foldbjerg, Esben S. Sørensen, Duncan S. Sutherland
Abstract
Focal adhesion development in cells adherent to surface bound fibronectin presented as 200, 500, or 1000 nm diameter circular patches or as homogeneous controls is studied by fluorescence and scanning electron microscopy. Fundamental cellular processes such as adhesion, spreading, focal adhesion and stress fiber formation are shown to be dependent on the spatial distribution of ligands at this scale. Large area samples enable the study of whole cell populations and opens for new potential applications.
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