Biocompatible Magnetofluorescent Probes: Luminescent Silicon Quantum Dots Coupled with Superparamagnetic Iron(III) Oxide
Citations Over TimeTop 1% of 2010 papers
Abstract
Luminescent silicon quantum dots (SiQDs) are gaining momentum in bioimaging applications, based on their unique combination of optical properties and biocompatibility. Here, we report the development of a multimodal probe that combines the optical properties of silicon quantum dots with the superparamagnetic properties of iron oxide nanoparticles to create biocompatible magnetofluorescent nanoprobes. Multiple nanoparticles of each type are coencapsulated within the hydrophobic core of biocompatible phospholipid-polyethyleneglycol (DSPE-PEG) micelles. The size distribution and composition of the magnetofluorescent nanoprobes were characterized by transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS). Enhanced cellular uptake of these probes in the presence of a magnetic field was demonstrated in vitro. Their luminescence stability in a prostate cancer tumor model microenvironment was demonstrated in vivo. This paves the way for multimodal silicon quantum-dot-based nanoplatforms for a variety of imaging and delivery applications.
Related Papers
- → Biocompatibility of Hemodiafilters(2016)7 cited
- Preparation and biocompatibility research of modified PPC biomaterial(2007)
- Effect of Surface Properties on the Biocompatibility of Polyurethane(2007)
- Research on Structure Biocompatibility and Cell Biocompatibility of Silk Fibroin Scaffolds for Tissue Engineering(2013)
- [Biocompatibility study of the UV surface modified Dacron material].(2004)