RGD-Modified Apoferritin Nanoparticles for Efficient Drug Delivery to Tumors
Citations Over TimeTop 1% of 2013 papers
Abstract
Ferritin (FRT) is a major iron storage protein found in humans and most living organisms. Each ferritin is composed of 24 subunits, which self-assemble to form a cage-like nanostructure. FRT nanocages can be genetically modified to present a peptide sequence on the surface. Recently, we demonstrated that Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys (RGD4C)-modified ferritin can efficiently home to tumors through RGD-integrin αvβ3 interaction. Though promising, studies on evaluating surface modified ferritin nanocages as drug delivery vehicles have seldom been reported. Herein, we showed that after being precomplexed with Cu(II), doxorubicin can be loaded onto RGD modified apoferritin nanocages with high efficiency (up to 73.49 wt %). When studied on U87MG subcutaneous tumor models, these doxorubicin-loaded ferritin nanocages showed a longer circulation half-life, higher tumor uptake, better tumor growth inhibition, and less cardiotoxicity than free doxorubicin. Such a technology might be extended to load a broad range of therapeutics and holds great potential in clinical translation.
Related Papers
- → Self-Assembly of Responsive Multilayered DNA Nanocages(2015)101 cited
- → Chemically coupled NiCoS/C nanocages as efficient electrocatalysts for nitrogen reduction reactions(2019)67 cited
- → MB11N12 (M = Fe–Zn) Nanocages for Cyanogen Chloride Detection: A DFT Study(2023)15 cited
- → Hollow Boron Nitride (BN) Nanocages and BN‐Nanocage‐Encapsulated Nanocrystals(2004)59 cited
- → Thermodynamic Stability of Discrete Fully Coordinated SiO2 Spherical and Elongated Nanocages(2004)53 cited