DNA Origami Nanopores for Controlling DNA Translocation
ACS Nano2013Vol. 7(7), pp. 6024–6030
Citations Over TimeTop 10% of 2013 papers
Silvia Hernández‐Ainsa, Nicholas A. W. Bell, Vivek V. Thacker, Kerstin Göpfrich, Karolis Misiunas, Maria Eugenia Fuentes-Perez, Fernando Moreno‐Herrero, Ulrich F. Keyser
Abstract
We combine DNA origami structures with glass nanocapillaries to reversibly form hybrid DNA origami nanopores. Trapping of the DNA origami onto the nanocapillary is proven by imaging fluorescently labeled DNA origami structures and simultaneous ionic current measurements of the trapping events. We then show two applications highlighting the versatility of these DNA origami nanopores. First, by tuning the pore size we can control the folding of dsDNA molecules ("physical control"). Second, we show that the specific introduction of binding sites in the DNA origami nanopore allows selective detection of ssDNA as a function of the DNA sequence ("chemical control").
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