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Synthetic Antiferromagnetic Nanoparticles as Potential Contrast Agents in MRI

ACS Nano2014Vol. 8(3), pp. 2269–2278

Citations Over TimeTop 16% of 2014 papers

Ruben Van Roosbroeck, W. Van Roy, Tim Stakenborg, Jesse Trekker, Antoine D’Hollander, Tom Dresselaers, Uwe Himmelreich, Jeroen Lammertyn, Liesbet Lagae

Abstract

We present the top-down synthesis of a novel type of MRI T2 contrast agent with great control over size and shape using a colloidal lithography technique. The resulting synthetic antiferromagnetic nanoparticles (SAF-NPs) yield improved relaxivities compared to superparamagnetic iron oxide alternatives (SPIONs). For T2 weighted imaging, the outer sphere relaxation theory has shown that the sensitivity of a T2 contrast agent is dependent on the particle size with an optimal size that exceeds the superparamagnetic limit of SPIONs. With the use of the interlayer exchange coupling effect, the SAF-NPs presented here do not suffer from this limit. Adjusting the outer sphere relaxation theory for spherical particles to SAF-NPs, we show both theoretically and experimentally that the SAF-NP size can be optimized to reach the r2 maximum. With measured r2 values up to 355 s–1 mM–1, our SAF-NPs show better performance than commercial alternatives and are competitive with the state-of-the-art. This performance is confirmed in an in vitro MRI study on SKOV3 cells.

Citations Over TimeTop 16% of 2014 papers

Abstract

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