Structure-Determining Step in the Hierarchical Assembly of Peptoid Nanosheets

Citations Over TimeTop 10% of 2014 papers

Abstract

Organic two-dimensional nanomaterials are of growing importance, yet few general synthetic methods exist to produce them in high yields and to precisely functionalize them. We previously developed an efficient hierarchical supramolecular assembly route to peptoid bilayer nanosheets, where the organization of biomimetic polymer sequences is catalyzed by an air-water interface. Here we determine at which stages of assembly the nanoscale and atomic-scale order appear. We used X-ray scattering, grazing incidence X-ray scattering at the air-water interface, electron diffraction, and a recently developed computational coarse-grained peptoid model to probe the molecular ordering at various stages of assembly. We found that lateral packing and organization of the chains occurs during the formation of a peptoid monolayer, prior to its collapse into a bilayer. Identifying the structure-determining step enables strategies to influence nanosheet order, to predict and optimize production yields, and to further engineer this class of material. More generally, our results provide a guide for using fluid interfaces to catalytically assemble 2D nanomaterials.

Related Papers

• → Helical Porous Protein Mimics Self-Assembled from Amphiphilic Dendritic Dipeptides*(2005)50 cited
• → Single Molecule Analysis of Self-Assembly Supramolecular Oligomers in Solution(2016)10 cited
• → Preparation of N-Substituted N-Arylsulfonylglycines and Their Use in Peptoid Synthesis(2015)7 cited
• → Versatile Oligo( N ‐Substituted) Glycines: The Many Roles of Peptoids in Drug Discovery(2004)46 cited
• → Self‐Processes — Programmed Supramolecular Systems(1995)32 cited