In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine

Citations Over TimeTop 1% of 2015 papers

Abstract

Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis, surface engineering, and in vivo active vasculature targeting of a new category of theranostic nanoparticle for future cancer management. Water-soluble photothermally sensitive copper sulfide nanoparticles were encapsulated in biocompatible mesoporous silica shells, followed by multistep surface engineering to form the final theranostic nanoparticles. Systematic in vitro targeting, an in vivo long-term toxicity study, photothermal ablation evaluation, in vivo vasculature targeted imaging, biodistribution and histology studies were performed to fully explore the potential of as-developed new theranostic nanoparticles.

Related Papers

• → Challenges in Realizing Selectivity for Nanoparticle Biodistribution and clearance: Lessons From Gold Nanoparticles(2017)135 cited
• → Applications of Mesoporous Silica-Encapsulated Gold Nanorods Loaded Doxorubicin in Chemo-photothermal Therapy(2020)24 cited
• → The biodistribution of NC100668 and the effect of excess NC100668 on the biodistribution and kidney retention of 99mTc-NC100668 in the rat(2007)4 cited
• → Synthesis, hypoxic radiosensitization and biodistribution of N- (5-nitroindazole-3-formyl) tyrosine sodium(2015)
• → Applications of Mesoporous\nSilica-Encapsulated Gold\nNanorods Loaded Doxorubicin in Chemo-photothermal Therapy(2020)