A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials
ACS Nano2009Vol. 3(7), pp. 1620–1627
Citations Over TimeTop 1% of 2009 papers
Abstract
The rate of expansion of nanomaterials calls for the consideration of appropriate toxicological paradigms in the safety assessment of nanomaterials. We advocate a predictive toxicological paradigm for the assessment of nanomaterial hazards. The predictive toxicological approach is defined as establishing and using mechanisms and pathways of injury at a cellular and molecular level to prioritize screening for adverse biological effects and health outcomes in vivo. Specifically as it relates to nanomaterials, a predictive approach has to consider the physicochemical properties of the material that leads to molecular or cellular injury and also has to be valid in terms of disease pathogenesis in whole organisms.
Related Papers
- → Soft Langmuir–Blodgett Technique for Hard Nanomaterials(2009)236 cited
- → Gold nanomaterials – The golden approach from synthesis to applications(2022)101 cited
- → Morphological Characterization of Nanomaterials(2018)63 cited
- → Controllable Synthesis and Biomedical Applications of Silver Nanomaterials(2011)87 cited
- → Nanomaterials for Sensing Applications: Introduction and Perspective(2012)10 cited