Three New Arylobenzofurans from Onobrychis ebenoides and Evaluation of Their Binding Affinity for the Estrogen Receptor
Journal of Natural Products2000Vol. 63(12), pp. 1672–1674
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Maria Halabalaki, Nektarios Aligiannis, Zoi Papoutsi, Sofia Mitakou, Paraskevi Moutsatsou, Constantine E. Sekeris, Alexios‐Léandros Skaltsounis
Abstract
Three new 2-phenyl-benzofurans, ebenfuran I, ebenfuran II, and ebenfuran III, were isolated from Onobrychis ebenoides. Their structures were elucidated on the basis of chemical and spectral data as 2-(2,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-benzofuran (1), 2-(2,4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-benzofuran (2), and 2-(2, 4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-5-(3-methyl-buten- 2-y l)-benzofuran (3). The affinity of these compounds for the estrogen receptor was studied using a receptor-binding assay.
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