In Vitro Antiplasmodial, Antiamoebic, and Cytotoxic Activities of Some Monomeric Isoquinoline Alkaloids
Journal of Natural Products2000Vol. 63(12), pp. 1638–1640
Citations Over TimeTop 18% of 2000 papers
Colin W. Wright, Sarah J. Marshall, Peter F. Russell, Mark Anderson, J. David Phillipson, Geoffrey C. Kirby, David C. Warhurst, Paul L. Schiff
Abstract
Twenty-one alkaloids have been assessed for activities against Plasmodium falciparum (multidrug- resistant strain K1) in vitro; 18 of these are reported for the first time. Two protoberberine alkaloids, dehydrodiscretine and berberine, were found to have antiplasmodial IC(50) values less than 1 M, while seven alkaloids-allocrytopine, columbamine, dehydroocoteine, jatrorrhizine, norcorydine, thalifendine, and ushinsunine-had values between 1 and 10 M. These results are discussed in the context of structure-activity relationships. Compounds were also assessed for antiamoebic and cytotoxic activities, but none was significantly active except for berberine, which was moderately cytotoxic.
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