Cancer Chemopreventive Agents. New Depsidones from Garcinia Plants
Journal of Natural Products2001Vol. 64(2), pp. 147–150
Citations Over TimeTop 19% of 2001 papers
Chihiro Ito, Masataka Itoigawa, Yoshitaka Mishina, Hiromi Tomiyasu, Marc Litaudon, Jean‐Pierre Cosson, Teruo Mukainaka, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa
Abstract
In a search for cancer chemopreventive agents from natural sources, chemical constituents of two kinds of Garcinia plants, Garcinia neglecta and Garcinia puat, collected in New Caledonia, were examined. Five new depsidones, garcinisidone-B (2), -C (3), -D (4), -E (5), and -F (6), were isolated, and their structures were determined by spectrometric analyses. Inhibitory effects of these depsidones on EBV-EA activation induced by TPA in Raji cells were also demonstrated.
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