Three New Peroxides from the Sponge Plakinastrella Species
Journal of Natural Products2001Vol. 64(2), pp. 262–264
Citations Over Time
Ying Chen, K. Brian Killday, Peter J. McCarthy, Rebecca Schimoler, Katherine Chilson, Claude P. Selitrennikoff, Shirley A. Pomponi, Amy E. Wright
Abstract
Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide-lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 micrograms/mL (SDB) and 3.1 micrograms/mL (RPMI) for 3, and 25 micrograms/mL (SDB) and 6.25 micrograms/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 micrograms/mL.
Related Papers
- → Relationship of Sponge Macrofauna with the Morphology of their Hosts in the North Aegean Sea(1992)56 cited
- → Advances in the production of sponge biomass Aplysina aerophoba—A model sponge for ex situ sponge biomass production(2006)29 cited
- → Sponge (2′,5′)oligoadenylate synthetase activity in the whole sponge organism and in a primary cell culture(2002)9 cited
- → Sponge Cell Adhesions(1978)7 cited
- → Η κλινική σημασία της απομόνωσης Aspergillus fumigatus σε ασθενείς με κυστική ίνωση(2017)