Three New Phenolic Compounds from a Manipulated Plant Cell Culture, Mirabilis jalapa
Journal of Natural Products2001Vol. 64(3), pp. 313–317
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Shuwei Yang, Rosa Ubillas, James B. McAlpine, Angela Stafford, Dawn M. Ecker, Monique Talbot, Bruce N. Rogers
Abstract
Bioassay-guided fractionation of an organic extract of the cell mass from a manipulated plant cell culture of Mirabilis jalapa led to the isolation and subsequent identification of three new phenolic compounds, 1, 2, and 3. The isoflavone 1 and dehydrorotenoid 2 were identified as the principal antifungal principles from this plant cell culture with IC50's of 25 and 48 μg/mL, respectively, against the test organism, Candida albicans DSY1024. The rotenoid 3 was inactive at 200 μg/mL in this assay.
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