Cytotoxic Polyacetylenes from the Twigs of Ochanostachys amentacea
Journal of Natural Products2001Vol. 64(2), pp. 246–248
Citations Over Time
Aiko Ito, Baoliang Cui, Daniel Chávez, Heebyung Chai, Young G. Shin, Kazuko Kawanishi, Leonardus B.S. Kardono, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn
Abstract
Bioassay-guided investigation of the twigs of Ochanostachys amentacea using LNCaP (hormone-dependent human prostate cancer) cells as a monitor led to the isolation of three alkynes, the known (S)-17-hydroxy-9,11,13,15-octadecatetraynoic acid (minquartynoic acid, 1) and two novel analogues, (S)-17,18-dihydroxy-9,11,13,15-octadecatetraynoic acid (2) and (S)-17-hydroxy-15E-octadecen-9,11,13-triynoic acid (3). Compounds 1-3 were tested against a panel of human tumor cell lines and found to be significantly cytotoxic.
Related Papers
- → Characterization of a novel metastatic prostate cancer cell line of LNCaP origin(2015)28 cited
- → THE USE OF THREE SIMPLE, RAPID BIOASSAYS ON FORTY‐TWO HERBICIDES*(1971)34 cited
- BACILLUS THURINGIENSIS BIOASSAY METHODOLOGY(2000)
- Inhibitive effect of androgen receptor antisense RNA on tumorigenesis of human prostate cancer cell LNCaP(2003)
- Establishment of androgen-independent human prostate cancer cell line model LNCaP-AI(2008)