Microxine, a New cdc2 Kinase Inhibitor from the Australian Marine Sponge Microxina Species
Journal of Natural Products2001Vol. 64(4), pp. 525–526
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K. Brian Killday, Donna Yarwood, Matthew A. Sills, Peter T. Murphy, John N. A. Hooper, Amy E. Wright
Abstract
A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.
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