Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum
Journal of Natural Products2001Vol. 64(11), pp. 1483–1485
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Eun‐Kyoung Seo, Nam-Cheol Kim, Qiuwen Mi, Heebyung Chai, Monroe E. Wall, Mansukh C. Wani, Hernán A. Navarro, Jason P. Burgess, James G. Graham, Fernando Cabieses, Ghee Teng Tan, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn
Abstract
A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
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