Bioactive Saponins from Acacia tenuifolia from the Suriname Rainforest
Journal of Natural Products2002Vol. 65(2), pp. 170–174
Citations Over Time
Youngwan Seo, Jeannine Hoch, Maged S. Abdel‐Kader, S. Malone, Iwan Derveld, Hermus Adams, Marga C. M. Werkhoven, Jan H. Wisse, Stephen W. Mamber, James M. Dalton, David G. I. Kingston
Abstract
Bioassay-guided fractionation of the MeOH extract of Acacia tenuifolia using the engineered yeast strains 1138, 1140, 1353, and Sc7 as the bioassay tool resulted in the isolation of the three new saponins 3, 5, and 6 and the three known saponins 1, 2, and 4. The structures of the new compounds were established on the basis of HRMS, 1D and 2D NMR spectral data on the intact saponins, and GC-MS analyses of the sugars. Compounds 1,2 and 5,6 showed cytotoxicity against mammalian cell lines.
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