Bioactive Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella globostellata
Journal of Natural Products2002Vol. 65(2), pp. 210–214
Citations Over TimeTop 15% of 2002 papers
Deniz Taşdemir, Gina C. Mangalindan, Gisela P. Concepción, Sheryl M. Verbitski, Sridhar K. Rabindran, Miriam Miranda, Michael Greenstein, John N. A. Hooper, Mary Kay Harper, Chris M. Ireland
Abstract
Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively.
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