Chemical Constituents of Calophyllum brasiliense. 2. Structure of Three New Coumarins and Cancer Chemopreventive Activity of 4-Substituted Coumarins
Journal of Natural Products2003Vol. 66(3), pp. 368–371
Citations Over TimeTop 15% of 2003 papers
Chihiro Ito, Masataka Itoigawa, Yoshitaka Mishina, Valdir Cechinel Filho, Fumio Enjo, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa
Abstract
Continuing our search for cancer chemopreventive agents from natural sources, we examined constituents of the stem bark of Calophyllum brasiliense. Three new 4-substituted coumarins named brasimarins A (2), B (3), and C (4) were isolated and characterized, along with 11 known coumarins belonging to the calanolides or inophyllums. We also discuss the inhibitory effects of these coumarins on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.
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