Bistratamides E−J, Modified Cyclic Hexapeptides from the Philippines Ascidian Lissoclinum bistratum
Journal of Natural Products2003Vol. 66(2), pp. 247–250
Citations Over TimeTop 10% of 2003 papers
Abstract
The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.
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