Induction of Apoptosis by Xanthones from Mangosteen in Human Leukemia Cell Lines
Journal of Natural Products2003Vol. 66(8), pp. 1124–1127
Citations Over TimeTop 10% of 2003 papers
Kenji Matsumoto, Yukihiro Akao, Emi Kobayashi, Kenji Ohguchi, Tetsuro Ito, Toshiyuki Tanaka, Munekazu Iinuma, Yoshinori Nozawa
Abstract
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
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