Potential Cancer Chemopreventive Flavonoids from the Stems of Tephrosia toxicaria
Citations Over Time
Abstract
A new butenylflavanone, (2S)-5-hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone (1), and a new rotenoid, 4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin (2), as well as three active flavonoids of previously known structure, isoliquiritigenin (3), genistein (4), and chrysoeriol (5), along with nine known inactive compounds, alpha-toxicarol (6), sumatrol, 6a,12a-dehydro-alpha-toxicarol, 11-hydroxytephrosin, obovatin, marmesin, lupenone, benzyl benzoate, and benzyl trans-cinnamate, were isolated from an ethyl acetate-soluble extract of the stems of Tephrosia toxicaria, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells to monitor chromatographic fractionation. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. All isolates were evaluated for their potential cancer chemopreventive properties utilizing an in vitro assay to determine quinone reductase induction. Selected compounds were tested in a mouse mammary organ culture assay to evaluate the inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced preneoplastic lesions.
Related Papers
- → Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis(2010)93 cited
- → The role of chalcones and flavanones in flavonoid biosynthesis(1968)49 cited
- → K 2 S 2 O 8 ‐Mediated Efficient Oxidative Deoximation of Flavonoid Oximes under Mild Reaction Conditions(2019)11 cited
- → The chalcone-flavanone isomerization affects in vitro bio-assays as exemplified with isoliquiritigenin from licorice(2012)
- → Dynamic Relationships between Bioactive 2'-Hydroxychalcones and their Flavanone Isomers in Licorice (Glycyrrhiza glabra L. and Glycyrrhiza uralensis Fisch. ex DC.)(2013)