Lactones from the Leaves of Litsea japonica and Their Anti-complement Activity
Journal of Natural Products2003Vol. 66(10), pp. 1388–1390
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Byung Sun Min, Sun-Young Lee, Jung Hee Kim, OK Kwon, Bo Young Park, Ren Bo An, Joong Ku Lee, Hyung In Moon, Tae Jin Kim, Young Ho Kim, Hyouk Joung, Hyeong Kyu Lee
Abstract
Two new lactones, litsealactone A (1) and litsealactone B (2), were isolated from the leaves of Litsea japonica, together with three known lactones, hamabiwalactone A (3), hamabiwalactone B (4), and akolactone B (5). Hamabiwalactone B (4) and akolactone B (5) significantly inhibited complement activity in an in vitro anti-complement assay, with IC(50) values of 149 and 58 muM, respectively.
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