Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia
Journal of Natural Products2003Vol. 66(10), pp. 1324–1327
Citations Over TimeTop 22% of 2003 papers
Ping‐Chung Kuo, Li-Shian Shi, Amooru G. Damu, Chung-Ren Su, Chieh-Hung Huang, Chih-Huang Ke, Jin-Bin Wu, Ai-Jeng Lin, Kenneth F. Bastow, Kuo‐Hsiung Lee, Tian-Shung Wu
Abstract
Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.
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