Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum
Journal of Natural Products2004Vol. 67(3), pp. 475–478
Citations Over TimeTop 14% of 2004 papers
Eric W. Schmidt, Carmen Raventós-Suárez, Marc Bifano, Ana T. Menendez, Craig R. Fairchild, D. John Faulkner
Abstract
The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.
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