Nagelamides A−H, New Dimeric Bromopyrrole Alkaloids from Marine Sponge Agelas Species
Journal of Natural Products2004Vol. 67(8), pp. 1262–1267
Citations Over TimeTop 10% of 2004 papers
Tadashi Endo, Masashi Tsuda, Tadashi Okada, Shinya Mitsuhashi, Hiroshi Shima, Kunimi Kikuchi, Yuzuru Mikami, Jane Fromont, Jun’ichi Kobayashi
Abstract
Eight new dimeric bromopyrrole alkaloids, nagelamides A-H (1-8) and a monomeric one, 9,10-dihydrokeramadine (9), have been isolated from the Okinawan marine sponge Agelas sp., and the structures were elucidated from spectroscopic data. Nagelamides A-H (1-8) exhibited antibacterial activity against Gram-positive bacteria. Nagelamide G (7) inhibited protein phosphatase 2A activity.
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