BI-32169, a Bicyclic 19-Peptide with Strong Glucagon Receptor Antagonist Activity from Streptomyces sp.
Journal of Natural Products2004Vol. 67(9), pp. 1528–1531
Citations Over TimeTop 25% of 2004 papers
Olivier Potterat, Klaus Wagner, Gerd Gemmecker, Jürgen Mack, Carsten Puder, Regine Vettermann, Rüdiger Streicher
Abstract
A new bicyclic 19-peptide, BI-32169, has been isolated from the culture broth of Streptomyces sp. (DSM 14996). Its structure has been established by amino acid analysis, mass spectrometry, and 2D NMR analysis. BI-32169 consists exclusively of protein amino acids and is cyclized from the side chain of Asp(9) to the N-terminus of Gly(1). One disulfide bond between Cys(6) and Cys(19) forms a bicyclic structure. BI-32169 and its methyl ester derivative showed potent inhibitory activity against the human glucagon receptor (IC(50) 440 and 320 nM, respectively) in a functional cell-based assay.
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