Suaveolindole, a New Mass-Limited Antibacterial Indolosesquiterpene from Greenwayodendron suaveolens Obtained via High-Throughput Natural Products Chemistry Methods
Journal of Natural Products2005Vol. 68(1), pp. 122–124
Citations Over TimeTop 20% of 2005 papers
Hye‐Dong Yoo, Peadar Cremin, Lu Zeng, Eliane Garo, Caroline Williams, Chris M. Lee, Matt G. Goering, Mark O’Neil-Johnson, Gary R. Eldridge, Jin‐Feng Hu
Abstract
Utilizing high-throughput isolation, purification, and analysis methods applied to a natural products library, a new mass-limited antibacterial indolosesquiterpene, suaveolindole (1), was obtained from Greenwayodendron suaveolens. The miniaturization of the structure elucidation of 1 was performed primarily using the CapNMR probe. Compound 1 was found to possess significant in vitro antibacterial activity against the Gram-positive bacteria Bacillus subtilis (ATCC 43223), Staphylococcus aureus (ATTC 6538P), and methicillin-resistant Staphylococcus aureus (ATTC 33591), with MIC values of 4, 8, and 8 microg/mL, respectively.
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