Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces nodosus
Journal of Natural Products2005Vol. 68(2), pp. 240–243
Citations Over TimeTop 10% of 2005 papers
Rama Rao Manam, Sy Teisan, Donald J White, Benjamin Nicholson, Jennifer Grodberg, Saskia Neuteboom, Kin S. Lam, Deborah A. Mosca, G. Kenneth Lloyd, Barbara C. M. Potts
Abstract
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro.
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