Trichomycins A and B: Antibacterial Triterpenes from the New Species Tricholoma sp. AU1
Journal of Natural Products2005Vol. 68(3), pp. 409–412
Citations Over Time
Simon P. B. Ovenden, Jin Yu, Jill Bernays, Soo San Wan, Larissa J. Christophidis, Gian Sberna, R. M. TAIT, Howard G. Wildman, Dominique Lebeller, Denis Platel, Tom W. May, Barbara Meurer‐Grimes
Abstract
To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined.
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