Oblongifolins A−D, Polyprenylated Benzoylphloroglucinol Derivatives from Garcinia oblongifolia
Journal of Natural Products2006Vol. 69(5), pp. 774–777
Citations Over TimeTop 10% of 2006 papers
Wafaa Hamed, Solenn Brajeul, Florence Mahuteau‐Betzer, Odile Thoison, Stéphane Mons, Bernard Delpech, Nguyen Van Hung, Thierry Sévenet, Christian Marazano
Abstract
Oblongifolins A-D (2-5), four new polyprenylated 3,4-dihydroxybenzoylphloroglucinol compounds, were isolated from the bark of Garcinia oblongifolia collected in Vietnam. The bark was also found to contain the known compounds camboginol and guttiferone B. Extraction of the leaves gave 2 and camboginol. Details of the structure elucidation of 2-5 and stereochemical comparisons with known natural derivatives of general formula 1a,b are presented. The biological activity of these compounds concerning interactions with tubulin was investigated.
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