Synthesis of Salvinorin A Analogues as Opioid Receptor Probes
Journal of Natural Products2006Vol. 69(6), pp. 914–918
Citations Over TimeTop 12% of 2006 papers
Kevin Tidgewell, Wayne W. Harding, Anthony Lozama, Howard Cobb, Kushal Shah, Pavitra Kannan, Christina M. Dersch, Damon A. Parrish, Jeffrey R. Deschamps, Richard B. Rothman, Thomas E. Prisinzano
Abstract
Several neoclerodanes, such as salvinorin A (1) and herkinorin (3), have recently been shown to possess opioid receptor activity in vitro and in vivo. To explore the structure-affinity relationships of this interesting class of compounds, we have synthesized a series of analogues from 1 isolated from Salvia divinorum. Here, we report the semisynthesis of neoclerodane diterpenes and their structure-affinity relationships at opioid receptors. This work will allow the further development of novel opioid receptor ligands.
Related Papers
- → Recent advances in selective opioid receptor agonists and antagonists(2003)163 cited
- → Are μ-opioid receptor polymorphisms important for clinical opioid therapy?(2005)144 cited
- → Receptor‐selective changes in µ‐, δ‐ and κ‐opioid receptors after chronic naltrexone treatment in mice(2003)74 cited
- → Evidence for Multiple Opioid Receptors in the Human Posterior Pituitary(1996)29 cited
- → Problems and Approaches in Studying Membrane Opioid Receptors(1991)1 cited